Assessment of the Additive Effect of Oral Streptomycin with Traditional Regimen Therapy to Eradicate H-Pylori
DOI:
https://doi.org/10.59675/U228Keywords:
gastric ulcer, H pylori, triple therapy, streptomycin, urea breath test.Abstract
Recently, an increased incidence of gastrointestinal disorders due to the overgrowth of H. pylori bacteria has been noticed remarkably. One of the clinical manifestations of H. pylori overgrowth is the increased incidence of gastric ulcers. The first line of therapy that is used frequently is triple antibiotic therapy plus gastric reducing agents, notably proton pump inhibitors (P.P.Is). Streptomycin (SM) is an injectable aminoglycoside antibiotic that has enhanced activity on gran-negative microbes. To evaluate the additive effect of SM when used orally on eradicating H. pylori by standard triple therapy. 109 patients were enrolled in this study with a gastroenterologist diagnosed with gastric ulcer caused by H. pylori colonization; 60 patients received triple therapy with oral SM, and the rest received only standard triple therapy. After 14 days of treatment, a urea breath test was done again (after baseline reading), and statistical analysis was performed to evaluate the effect of SM. The Results showed that there was a significant difference in the degree of response to triple therapy plus SM as compared to using triple therapy alone.
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Bordin DS, Voynovan IN, Andreev DN, Maev IV. Current Helicobacter pylori diagnostics. Diagnostics. 2021;11(8):1458. DOI: https://doi.org/10.3390/diagnostics11081458
Alexander SM, Retnakumar RJ, Chouhan D, et al. Helicobacter pylori in human stomach: the inconsistencies in clinical outcomes and the probable causes. Front Microbiol. 2021;12:713955. DOI: https://doi.org/10.3389/fmicb.2021.713955
Cho J, Prashar A, Jones NL, Moss SF. Helicobacter pylori infection. Gastroenterol Clin. 2021;50(2):261-282. DOI: https://doi.org/10.1016/j.gtc.2021.02.001
Sousa C, Ferreira R, Azevedo NF, et al. Helicobacter pylori infection: from standard to alternative treatment strategies. Crit Rev Microbiol. 2022;48(3):376-396. DOI: https://doi.org/10.1080/1040841X.2021.1975643
Gisbert JP. Empirical or susceptibility-guided treatment for Helicobacter pylori infection? A comprehensive review. Therapeutic Advances in Gastroenterology. 2020 Nov;13:1756284820968736. DOI: https://doi.org/10.1177/1756284820968736
Lopes D, Nunes C, Martins MCL, et al. Eradication of Helicobacter pylori: past, present and future. J Control Release. 2014;189:169-186. DOI: https://doi.org/10.1016/j.jconrel.2014.06.020
Aumpan N, Mahachai V, Vilaichone RK. Management of Helicobacter pylori infection. JGH Open. 2023;7(1):3-15. DOI: https://doi.org/10.1002/jgh3.12843
Jimenez Madrid AM, Ivey MLL. An overview of streptomycin resistance in Erwinia amylovora from Ohio apple orchards. Plant Health Prog. 2023;24(1):56-61. DOI: https://doi.org/10.1094/PHP-08-22-0074-RS
Li D, Fang H, Gai Y, et al. Metabolic engineering and optimization of the fermentation medium for vitamin B₁₂ production in Escherichia coli. Bioprocess Biosyst Eng. 2020;43:1735-1745. DOI: https://doi.org/10.1007/s00449-020-02355-z
Torp AM, Kamguyan K, Christfort JF, et al. Local delivery of streptomycin in microcontainers facilitates colonization of streptomycin-resistant Escherichia coli in the rat colon. Appl Environ Microbiol. 2022;88(14) DOI: https://doi.org/10.1128/aem.00734-22
Fadhl ALzamili, Nisreen Jawad Kadhim. Diagnosis study of Peptic Ulcers in Iraqi Patients students. Aca. Intl. J. Med. Sci. 2024; 2 (2) 12-19. DOI: https://doi.org/10.59675/M223 DOI: https://doi.org/10.59675/M223
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