The Impact of COVID-19 on White Blood Cell Subpopulations and Inflammatory Markers
DOI:
https://doi.org/10.59675/U2210Keywords:
COVID-19, Lymphocytes, Neutrophils, CRP, D-dimerAbstract
Background: COVID-19 is a disease of the zoonosis class and much has come to light since the onset of the pandemic in December 2019. Understanding COVID-19 pathophysiology is crucial for its effective treatment. The present study is conducted to observe the haematological changes associated with COVID-19 infection among a cohort of Iraqi patients.
Methods and Design: A retrospective cohort study involving confirmed (60) COVID-19 patients and (20) individuals in the control group admitted to Al Karama Teaching Hospital in Al-Kut Wasit Province, Iraq. Data captured included complete blood counts (CBC), C-reactive protein (CRP), and D-dimer levels. The statistical analysis covered t-tests for between-group comparison and multiple linear regression to ascertain the associations between the haematological parameters.
Results: The COVID-19 patients had a significantly higher total white blood cell count, with a mean of 17.1575 than the control groups of 8.7005 (p > 0.001). COVID-19 patients also had significantly greater mean lymphocyte counts (mean 55.365) compared to controls (mean 29.79; p > 0.001), suggesting the presence of lymphocytosis. The COVID-19 patients also showed significantly higher mean neutrophil count (mean 82.9205) than the control group (mean 60.369; p > 0. The mean levels of CRP were 75.74667 in COVID-19 patients, which is significantly higher compared to 3.11 as observed in the control group (p > 0.001). Similarly, the mean D-dimer levels were higher in COVID-19 patients at 2319.7 compared to 336.65 in the control group (p > 0.001). The correlation analysis shows a high negative correlation between WBCs and neutrophils and a moderate positive correlation between CRP and D-dimer, which reflects the complex interplay between inflammatory and coagulation processes.
Conclusion: This study highlights striking haematological changes in COVID-19, characterized by lymphocytosis, neutrophilia, and activation of inflammatory and coagulation markers. It underlines the importance of monitoring these parameters for better patient management. More research is needed to explore therapeutic interventions targeting these specific immune and coagulation responses in COVID-19.
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References
Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF. The proximal origin of SARS-CoV-2. Nature Medicine. 2020;26(4):450-2. DOI: https://doi.org/10.1038/s41591-020-0820-9
Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270-3. DOI: https://doi.org/10.1038/s41586-020-2012-7
Singh D, Yi SV. On the origin and evolution of SARS-CoV-2. Experimental & Molecular Medicine. 2021;53(4):537-47. DOI: https://doi.org/10.1038/s12276-021-00604-z
Ramos-Casals M, Brito-Zerón P, Mariette X. Systemic and organ-specific immune-related manifestations of COVID-19. Nature Reviews Rheumatology. 2021;17(6):315-32. DOI: https://doi.org/10.1038/s41584-021-00608-z
Wong RSY. Inflammation in COVID-19: from pathogenesis to treatment. International journal of clinical and experimental pathology. 2021;14(7):831-44. DOI: https://doi.org/10.33140/JCEI.07.02.02
Klok FA, Kruip M, van der Meer NJM, Arbous MS, Gommers D, Kant KM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thrombosis research. 2020;191:145-7. DOI: https://doi.org/10.1016/j.thromres.2020.04.013
Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. Journal of thrombosis and haemostasis : JTH. 2020;18(4):844-7. DOI: https://doi.org/10.1111/jth.14768
Pepys MB, Hirschfield GM. C-reactive protein: a critical update. The Journal of Clinical Investigation. 2003;111(12):1805-12. DOI: https://doi.org/10.1172/JCI200318921
Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet (London, England). 2020;395(10229):1033-4. DOI: https://doi.org/10.1016/S0140-6736(20)30628-0
Stringer D, Braude P, Myint PK, Evans L, Collins JT, Verduri A, et al. The role of C-reactive protein as a prognostic marker in COVID-19. International journal of epidemiology. 2021;50(2):420-9. DOI: https://doi.org/10.1093/ije/dyab012
Lazzaroni MG, Piantoni S, Masneri S, Garrafa E, Martini G, Tincani A, et al. Coagulation dysfunction in COVID-19: The interplay between inflammation, viral infection and the coagulation system. Blood reviews. 2021;46:100745. DOI: https://doi.org/10.1016/j.blre.2020.100745
Guan W-j, Ni Z-y, Hu Y, Liang W-h, Ou C-q, He J-x, et al. Clinical characteristics of 2019 novel coronavirus infection in China. medRxiv. 2020:2020.02.06.20020974.
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. DOI: https://doi.org/10.1001/jama.2020.1585
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet (London, England). 2020;395(10229):1054-62. DOI: https://doi.org/10.1016/S0140-6736(20)30566-3
Tay MZ, Poh CM, Rénia L, MacAry PA, Ng LFP. The trinity of COVID-19: immunity, inflammation and intervention. Nature Reviews Immunology. 2020;20(6):363-74. DOI: https://doi.org/10.1038/s41577-020-0311-8
Sakka M, Connors JM, Hékimian G, Martin-Toutain I, Crichi B, Colmegna I, et al. Association between D-Dimer levels and mortality in patients with coronavirus disease 2019 (COVID-19): a systematic review and pooled analysis. Journal de medecine vasculaire. 2020;45(5):268-74. DOI: https://doi.org/10.1016/j.jdmv.2020.05.003
Kashte S, Gulbake A, El-Amin Iii SF, Gupta A. COVID-19 vaccines: rapid development, implications, challenges and future prospects. Human cell. 2021;34(3):711-33. DOI: https://doi.org/10.1007/s13577-021-00512-4
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